Research Progress of Catalytic Synthesis of Benzimidazole Derivatives

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...

synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives

NaHSO 4 - SiO 2 promoted synthesis of Benzimidazole derivatives

a library of benzimidazole derivatives have been prepared through the reaction of o-phenylenediamine and aldehydes in the presence of catalytic amount of silica supported sodium hydrogen sulphate (NaHSO4-SiO2) under refluxing in ethanol solvent to obtained excellent yields. This method is simple, convenient, environmental friendly, reusable, efficient and practical.

Synthesis and antimicrobial activities of some new benzimidazole derivatives.

Some benzimidazolylbenzamides were synthesized and their antimicrobial activities against Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans evaluated. It was shown that the compound 14 exhibited the best activity against B. subtilis, P. aeruginosa and C. albicans.

Anticonvulsant evaluation of some newer benzimidazole derivatives: design and synthesis.

A series of new 2-[(1-substituted phenylethylidine) hydrazine]-N-phenyl-1H-benzo[d]imidazole-1-carbothioamides (4a-n) were designed and synthesized to have the pharmacophoric elements essential for anticonvulsant activity. The key step in the synthesis of the title compounds involves the reaction of 2-mercaptobenzimidazole with hydrazine hydrate, substituted acetophenones and phenylisothiocyana...